导师简介

姓名：张炜，性别：男，政治面貌：中共党员，学历：研究生，学位：博士，职称：副主任医师

博、硕导师：博导，本岗位工作年数：5年

研究方向：神经系统罕见病、遗传病、危重症

荣誉称号：山西医科大学第一医院2024年度“优秀青年组长”

学术任职：中华医学会神经病学分会神经遗传学组委员，山西省医学会神经病学分会常务委员

近五年承担科研课题情况：

1.国家自然科学基金面上项目 项目名称：ETFDH基因单杂合变异导致核黄素反应性多种酰基辅酶A脱氢酶缺乏症的机制研究，项目编号:82471432

2.山西省自然科学基金面上项目 项目名称：视神经萎缩伴共济失调家系中致病基因功能验证与药物筛选，项目编号：20210302123245

代表性论著及近五年的代表性论文（限10项以内）：

[1] ZHANG H, ZHAI F, SU M, ZHANG Y, MA J, ZHAO J, WANG J, CHANG X, LIU Y, GUO J,ZHANG W. Comparison of intravenous efgartigimod and intravenous immunoglobulin in patients with Guillain-Barre syndrome [J]. Orphanet J Rare Dis, 2025, 20(1): 529.

[2] ZHANG H, MA J, SU M, ZHAO J, DUAN W, WANG J, LIU D, GUO J, CHANG X,ZHANG W, ZHAO R. The difference of variation types between late-onset multiple acyl-CoA dehydrogenase deficiency patients carrying biallelic and single heterozygous variations in ETFDH: a systematic review and meta-analysis [J]. Orphanet J Rare Dis, 2025, 20(1): 310.

[3] WANG J, ZHAO R, MA J, QIN J, ZHANG H, GUO J, CHANG X,ZHANG W. Biallelic FDXR mutations induce ferroptosis in a rare mitochondrial disease with ataxia [J]. Free Radic Biol Med, 2025, 230: 248-62.

[4] ZHANG H, MA J, FENG Y, MA H, LIU D, PANG X, CHANG X, ZHAO R, WANG J, GUO J,ZHANG W. Efgartigimod in the treatment of Guillain-Barre syndrome [J]. Journal of neurology, 2024, 271(6): 3506-11.

[5] MA J, ZHANG H, ZHAO J, SU M, FENG Y, YUAN X, LIU D, PANG X, ZHAO R, WANG J, DUAN W, CHANG X, GUO J,ZHANG W. Efgartigimod versus intravenous immunoglobulin in the treatment of patients with impending myasthenic crisis [J]. Sci Rep, 2024, 14(1): 28394.

[6] MA J, ZHANG H, PANG X, ZHANG J, ZHAO R, WANG J, CHANG X, GUO J,ZHANG W. Diaphragmatic ultrasonography as a predictor of respiratory muscle fatigue in myasthenia gravis [J]. Muscle & nerve, 2024, 69(2): 199-205.

[7] MA J, ZHANG H, MENG B, QIN J, LIU H, PANG X, ZHAO R, WANG J, CHANG X, GUO J,ZHANG W. CGG Repeat Expansion in NOTCH2NLC Causing Overlapping Oculopharyngodistal Myopathy and Neuronal Intranuclear Inclusion Disease With Diffusion Weighted Imaging Abnormality in the Cerebellum [J]. J Clin Neurol, 2024, 20(6): 580-90.

[8] MA J, ZHANG H, LIANG F, LI G, PANG X, ZHAO R, WANG J, CHANG X, GUO J,ZHANG W. The male-to-female ratio in late-onset multiple acyl-CoA dehydrogenase deficiency: a systematic review and meta-analysis [J]. Orphanet J Rare Dis, 2024, 19(1): 72.

[9]ZHANG H, ZHAO R, MA J, ZHANG J, WANG J, CHANG X, GUO J,ZHANG W. Hyperhomocysteinemia in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency [J]. Muscle & nerve, 2023.

[10]ZHANG W, MA J, SHI J, HUANG S, ZHAO R, PANG X, WANG J, GUO J, CHANG X. GGC repeat expansions in NOTCH2NLC causing a phenotype of lower motor neuron syndrome [J]. Journal of neurology, 2022, 269(8): 4469-77.