导师简介

姓名：张晓东 性别：男 政治面貌：群众 学历：研究生 学位： 医学博士 职称：主任医师

博、硕导师：硕导 本岗位工作年数：28年

研究方向：慢性肾脏病防治

荣誉称号：无

学术任职：目前担任《中国中西医结合肾病杂志》编委；山西医学会肾病分会副主委；中华老年医学肾病学组委员；中国医师协会中西医结合分会全国委员；中国医师协会山西中西医结合分会副会长；中国医师协会山西肾病分会常务委员；中国中西医结合学会山西肾病分会委员；。

近五年承担科研课题情况：

(1)山西省科技厅,自然科学研究面上项目, 202403021211152,益肾胶囊上调SIRT6/HIF-1a信号通路改善糖尿病肾病肾小管上皮细胞焦亡的机制, 2024-07至2027-07,在研,主持

(2)山西省科技厅,自然科学研究面上项目, 202303021211205,黄芪甲苷调节HIF-1α介导的自噬改善腹膜透析相关腹膜纤维化的机制研究, 2024-01至2026-12,在研,参与

代表性论著及近五年的代表性论文（限10项以内）：

1.Liu T, Cao Y, Liang N, Ma X, Fang JA, Zhang X. Investigating the causal association between gut microbiota and type 2 diabetes: a meta-analysis and Mendelian randomization. Front Public Health. 2024 Jun 19;12:1342313.

2.Liu T, Li R, Wang X, Gao X, Zhang X. Benefits of SGLT2 inhibitors combining with renin-angiotensin-system blockers on cardiovascular outcomes in chronic kidney disease patients: A systemic review and meta-analysis. Med Clin (Barc). 2022 Jul 22;159(2):65-72.

3.Liu T, Wang X, Li R, Zhang ZY, Fang J, Zhang X. Effects of Probiotic Preparations on Inflammatory Cytokines in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis. Curr Pharm Biotechnol. 2021;22(10):1338-1349.

4.Cao Y, Liang N, Kong K, Qiao X, Liu T, Fang JA, Zhang X. CD163 as a Potential Biomarker-associated Immune Inflammation in Diabetes Mellitus: A Systematic Review and Bioinformatics Analysis. Endocr Metab Immune Disord Drug Targets. 2024;24(2):208-219.

5.Liang N, Ma X, Cao Y, Liu T, Fang JA, Zhang X. Mendelian Randomization Studies: Opening a New Window in the Study of Metabolic Diseases and Chronic Kidney Disease. Endocr Metab Immune Disord Drug Targets. 2024 Aug 20. doi: 10.2174/0118715303288685240808073238.

6.Qiao X, Kong K, Liu T, Jia Y, Fang J, Zhang X. Gut-Skin Axis: Unravelling the Link Between Gut Microbiome and Chronic Kidney Disease-Related Skin Lesions. Endocr Metab Immune Disord Drug Targets. 2024;24(1):39-49.

7.Kong K, Qiao X, Liu T, Wang X, Li R, Fang J, Zhang X. Identification of Novel Hub Genes Associated with Inflammation and Autophagy in Astragaloside Membranaceus ameliorates Lupus Nephritis by Bioinformatics Analysis and Molecular Dynamics Simulation. Comb Chem High Throughput Screen. 2025;28(2):306-318.

8.Cao Y, Liang N, Liu T, Fang J, Zhang X. Effect of SGLT2 Inhibitors and Metformin on Inflammatory and Prognostic Biomarkers in Type 2 Diabetes Patients. Endocr Metab Immune Disord Drug Targets. 2023;23(4):530-547.

9.Liu Y, Liu W, Zhang Z, Hu Y, Zhang X, Sun Y, Lei Q, Sun D, Liu T, Fan Y, Li H, Ding W, Fang J. Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy. Ren Fail. 2021 Dec;43(1):128-140.

10.Wang X, Li R, Liu T, Jia Y, Gao X, Zhang X.CD163in Macrophages: A Potential Biomarker for Predicting the Progression of Diabetic Nephropathy based on Bioinformatics Analysis. Endocr Metab Immune Disord Drug Targets. 2023;23(3):294-303.