导师简介

姓名：王宏勤 性别：男 政治面貌：中共党员

学历：研究生 学位：博士 职称：教授

博、硕导师：博导      本岗位工作年数：30年

研究方向：脑肿瘤、脑血管疾病基础与临床

荣誉称号：山西省首批“三晋英才”-拔尖骨干人才，山西省首批学术技术带头人，第一完成人获得山西省科技进步奖二等奖1项，山西省高校科技进步奖一等奖1项。

学术任职：山西医科大学神经外科硕导、博导，国家卫生健康委能力提升和继续教育神经外科专家委员会委员，山西省医学会神经外科专业委员会侯任主任委员，中国医师协会神经外科分会全国委员

近五年承担科研课题情况：

国家自然基金面上项目-MicroRNA-195 在人脑胶质瘤替莫唑胺化疗耐药中的作用及机制研究（81470115）

代表性论著及近五年的代表性论文（限10项以内）

1. Radiotherapy combined with anti-CEACAM1 immunotherapy to induce survival advantage in glioma.Discov Oncol. 2023 Mar 16;14(1):32.

2. MicroRNA-195 reverses the resistance to temozolomide through targeting cyclin E1 in glioma cells. Anticancer Drugs. 2019 Jan;30(1):81-88.

3. ANXA2 is a potential biomarker for cancer prognosis and immune infiltration: A systematic pan-cancer analysis.Front Genet. 2023 Jan 12;14:1108167.

4. Different changes in granulocyte-colony stimulating factor and its correlation with inflammatory biomarkers in patients after traumatic brain injury.Neuroreport. 2020 Mar 4;31(4):293-299.

5. Reduced expression of microRNA-497 is associated with greater angiogenesis and poor prognosis in human gliomas. Hum Pathol. 2016 Dec;58:47-53.

6. Abnormal expression of circulating and tumor-infiltrating carcinoembryonic antigen-related cell adhesion molecule 1 in patients with glioma.Oncol Lett. 2018 Mar;15(3):3496-3503.

7. Anti-miRNA-23a oligonucleotide suppresses glioma cells growth by targeting apoptotic protease activating factor-1.Curr Pharm Des. 2013;19(35):6382-9.

8. p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis.Mol Med Rep. 2015 Jun;11(6):4165-73.

9. Combined Blockade of T Cell Immunoglobulin and Mucin Domain 3 and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Results in Durable Therapeutic Efficacy in Mice with Intracranial Gliomas. Med Sci Monit. 2017 Jul 24;23:3593-3602.

10. The role of neuropeptide Y and aquaporin 4 in the pathogenesis of intestinal dysfunction caused by traumatic brain injury. J Surg Res. 2013 Oct;184(2):1006-12.