导师简介

姓名：徐隋意 性别：男 政治面貌：中共党员 学历：博士

学位：博士 职称：主任医师 博、硕导师：硕士生导师

本岗位工作年数：11年

研究方向：头痛的基础与临床

荣誉称号：三晋英才，中国卒中学会优秀科技工作者

学术任职：

中国医师协会神经内科医师分会头痛与感觉障碍学组委员

中国研究型医院学会头痛与感觉障碍专业委员会常务委员

中国卒中学会青年理事会理事

中国老年医学学会神经医学委员会委员/青年副主任委员

山西省健康协会头痛专业委员会主任委员

山西省医师协会神经内科医师分会脑与脊髓损害学组副主任委员

山西省医学会心身医学专业委员会神经内科学组副主任委员

山西省医学会神经病学专业委员会头痛学组副组长

Stroke and Vascular Neurology编委（1区）

近五年承担科研课题情况：

1. 2025年国际多中心临床研究：一项评价Atogepant用于月经性偏头痛预防性治疗的疗效、安全性和耐受性的多中心、随机、双盲、安慰剂对照III期研究，分中心PI（78万）

2. 2024年全国多中心临床研究：中国偏头痛治疗真实世界研究，分中心PI（12万）

3. 2023年山西省基础研究计划：低温通过调控线粒体自噬保护OGD/R脑血管内皮细胞的机制研究，项目编号：202303021221222（8万）

4. 2022年山西省人社厅省级博士基金项目：HTRA1基因下调与过表达对小鼠脑微血管内皮细胞功能影响的研究，项目编号：SD2215（5万）

5. 2021年136兴医工程专项：急性缺血性卒中血管再通后桥接低温灌注对线粒体质量控制的分子机制（13万）

代表性论著及近五年的代表性论文（限10项以内）：

1.Sun WX, Chen TY, Song MM,et al. Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing. Frontiers in neurology 2025; DOI: 10.3389/fneur. 2025.1561000.（通讯作者）

2.Song SN, Li HJ, Liang JL, et al. Lentivirus-Mediated Missense Mutation in HtrA1 Leads to Activation of the TGF-β/Smads Pathway and Increased Apoptosis of Mouse Brain Microvascular Endothelial Cells via the Oxidative Stress Pathway. Journal of integrative neuroscience 2024; 23: 201. 2024/11/30. DOI: 10.31083/j.jin2311201.（通讯作者）

3.Yang MF, Ren DX, Pan X, et al. The Role of Astrocytes in Migraine with Cortical Spreading Depression: Protagonists or Bystanders? A Narrative Review. Pain and therapy 2024 2024/05/15. DOI: 10.1007/s40122-024-00610-9.（通讯作者）

4.Zhang S, Xu S, Chen C, et al. Profile of Chinese Cluster Headache Register Individual Study (CHRIS): Clinical characteristics, diagnosis and treatment status data of 816 patients in China. Cephalalgia : an international journal of headache 2024; 44: 3331024241235193. 2024/03/19. DOI: 10.1177/03331024241235193.（共同第一作者）

5.Xu SY, Zhang Q and Li CX. Paroxysmal Sympathetic Hyperactivity After Acquired Brain Injury: An Integrative Review of Diagnostic and Management Challenges. Neurology and therapy 2024; 13: 11-20. 2023/11/10. DOI: 10.1007/s40120-023-00561-x.

6.Xu SY, Song MM, Pan X, et al. Rectangular method: a modified technique for sampling the ischemic border zone in a rat model of transient middle cerebral artery occlusion. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2023; 56: e13140. 2023/12/13. DOI: 10.1590/1414-431X2023e13140.

7.Xu SY, Li L, Sun WX, et al. Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option. Frontiers in neurology 2023; 14: 1179391. 2023/07/10. DOI: 10.3389/fneur.2023.1179391.

8.Xu SY, Li HJ, Li S, et al. Heterozygous Pathogenic and Likely Pathogenic Symptomatic HTRA1 Variant Carriers in Cerebral Small Vessel Disease. International journal of general medicine 2023; 16: 1149-1162. 2023/04/06. DOI: 10.2147/ijgm.S404813.

9.Hou SJ, Zhang SX, Li Y, et al. Rapamycin Responds to Alzheimer's Disease: A Potential Translational Therapy. Clinical interventions in aging 2023; 18: 1629-1639. 2023/10/09. DOI: 10.2147/cia.S429440.（通讯作者）

10.Xu SY, Song MM, Li L, et al. Adie's Pupil: A Diagnostic Challenge for the Physician. Medical science monitor: international medical journal of experimental and clinical research 2022; 28: e934657. 2022/03/20. DOI: 10.12659/msm.934657.

11.Xu SY, Wang RJ, Zhang L, et al. Basilar dolichoectasia with intermural hematoma accompanied by cerebral microbleeds and white matter hyperintensities: A case report. Medicine 2021; 100: e27022. 2021/08/21. DOI: 10.1097/md.0000000000027022.

12.Xu SY, Song MM, Liu DY, et al. Contrast-induced encephalopathy with significantly elevated levels of cerebrospinal fluid protein. British journal of neurosurgery 2021: 1-5. 2021/08/27. DOI: 10.1080/02688697.2021.1970113.

13.Xu SY, Liang JL, Li HJ, et al. Type II Alexander disease with fragile X mental retardation 1 gene mutation. Clinical neurology and neurosurgery 2021; 211: 107023. 2021/11/21. DOI: 10.1016/j.clineuro.2021.107023.

14.Xu SY, Li HJ, Huang J, et al. Migraine with Brainstem Aura Accompanied by Disorders of Consciousness. Journal of pain research 2021; 14: 1119-1127. 2021/04/29. DOI: 10.2147/jpr.S305483.

15.Xu SY, Z, M.; Wu, X. W.; Li, L.; Li, C. X. The mechanisms of limb hemiplegia after ipsilateral brain hemisphere stroke. Int J Clin Exp Med 2020; 13: 7386-7392.

16.Xu SY, Li ZX, Wu XW, et al. Frequency and Pathophysiology of Post-Seizure Todd's Paralysis. Medical science monitor: international medical journal of experimental and clinical research 2020; 26: e920751. 2020/03/07. DOI: 10.12659/msm.920751.

17.Xu SY, Li CX, Li LY, et al. Wallerian degeneration of bilateral cerebral peduncles after acute carbon monoxide poisoning. BMC neurology 2020; 20: 96. 2020/03/19. DOI: 10.1186/s12883-020-01677-5.