导师简介

姓名：李艳丽性别：女政治面貌：中共党员学历：研究生 学位：博士职称：副教授

博、硕导师：硕导本岗位工作年数：5

研究方向：衰老及认知障碍的机制研究

荣誉称号：无

学术任职：无

近五年承担科研课题情况：

国家自然科学基金青年项目 项目名称：肠道菌群调控Treg细胞参与衰老相关认知下降的作用和机制研究，项目编号: 82101641

山西省基础研究计划青年项目 项目名称：肠道菌群通过抑制炎症促进健康老龄化，项目编号: 20210302124173

代表性论著及近五年的代表性论文（限10项以内）：

1. Yu L, Liu MM, Guan MQ, Wang R, Yang XR, Zhang XM, Wei JJ, Wu SF, Gu H, Fu Q, Guo JH,Li YL. Peripheral CD4+ T cell phenotype and brain microglial activation associated with cognitive heterogeneity in aged rats [J]. Immun Ageing. 2024 Nov 14;21(1):81.

2. Guan MQ, Yu L, Gu H, Fu Q, Liu MM, Li K, Yang XR, Framroze B, Guo JH, Wei JJ,Li YL. Protein hydrolysate from Atlantic salmon (Salmo salar) improves aging-associated neuroinflammation and cognitive decline in rats by reshaping the gut microbiota and Th17/Treg balance [J]. Int J Biol Macromol. 2025 Feb 19;306(Pt 1):141270.

3.Li Y, Ning L, Yin Y, Wang R, Zhang Z, Hao L, Wang B, Zhao X, Yang X, Yin L, Wu S, Guo D, Zhang C. Age-related shifts in gut microbiota contribute to cognitive decline in aged rats. Aging (Albany NY). 2020 May 1;12(9):7801-7817.

4.Li Y, Wang R, Li Q, Wang YJ, Guo J. Gut Microbiota and Alzheimer's Disease: Pathophysiology and Therapeutic Perspectives. J Alzheimers Dis. 2021;83(3):963-976.

5.Li YL, Chang XR, Ma JT, Zhao X, Yin LT, Yan LJ, Guo JH, Zhang C, Yang XR. Activation of peripheral group III metabotropic glutamate receptors suppressed formalin-induced nociception. Clin Exp Pharmacol Physiol. 2022 Feb;49(2):319-326.

6.李艳丽,杨小荣,张策,郭军红.抗生素对大鼠肠道菌群和认知行为的影响[J].安徽医科大学学报,2022,57(09):1447-1452.

7.Hao L, Mi J, Song L, Guo Y,Li Y, Yin Y, Zhang C. SLC40A1 Mediates Ferroptosis and Cognitive Dysfunction in Type 1 Diabetes. Neuroscience. 2021 May 21;463:216-226.

8.Huang S, Wang J, Fan DY, Luo T,Li Y, Tu YF, Shen YY, Zeng GH, Chen DW, Wang YR, Chen LY, Wang YJ, Guo J. The association of serum uric acid with cognitive impairment and ATN biomarkers. Front Aging Neurosci. 2022 Jul 18;14:943380.