姓名：张丽 性别：女政治面貌：农工党党员

学历：研究生学位：博士职称： 副教授

博、硕导师：硕士生导师 本岗位工作年数：5年

研究方向：再生医学与表观遗传学

荣誉称号：无

学术任职：山西医科大学第一医院干（体）细胞临床研究学术委员会秘书，山西省抗癌协会肿瘤样本整合研究专业委员会委员等

近五年承担科研课题情况：

1、国家自然科学基金（青年项目），项目名称：m6A修饰FNDC5在叶酸无应答致神经管畸形发生的作用及机制研究，项目编号：82201319

2、山西省科学技术厅（自由探索类青年基金），项目名称：S-腺苷甲硫氨酸调控m6A修饰致神经管畸形发生的机制研究，项目编号：20210302124291

3、山西医科大学“百亿工程”校级基金，项目名称：核黄素靶向FGF1在维甲酸介导的神经管畸形的机制研究，项目编号：BYJL06

4、山西省教育厅（高等学校一般性教学改革创新项目），项目名称：研究生教学质量管理数字化、信息化建设研究与实践，项目编号：2024JG086

5、山西省教育厅（高等学校一般性教学改革创新项目），项目名称：基于学习通平台的线上多维动画与临床化教学在生物化学教学中的应用与探索，项目编号：J20230448

6、山西省卫生健康委员会（一般项目），项目名称：M6A RNA甲基化调控Wnt/β-catenin信号通路参与神经管畸形的机制研究，项目编号：2020090

7、山西省教育厅（科技创新项目），项目名称：METTL3介导的m6A修饰通过调控Wnt/β-catenin通路致神经管畸形发生的机制研究，项目编号：2021L181

8、山西省卫生健康委员会（实验室专项），项目名称：PD-1/PD-L1信号通路在肝癌肝移植免疫应答中的作用机制研究，项目编号：2022142

代表性论著及近五年的代表性论文（限10项以内）：

1、Li Zhang^#*，Xiaona Zhang^#，Yurong Liu^#，Kaixin Wei^#，Huijing Ma，Li Xia，Rui Cao，Yuqing Sun，Ronghua Zheng，Xiuwei Wang*，Bingmei Chang*. Ethionine‐induced S‐adenosylmethionine deficiency suppressed H3K27me3 and cell differentiation during neural tube development in mice. J Cell Physiol. 2025 Jan;240(1):e31452.

2、Li Zhang#, Dandan Li#, Yurong Liu, Xiaona Zhang, Kaixin Wei, Xiaorong Zhao, Huijing Ma, Bo Niu, Rui Cao*, Xiuwei Wang*. Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation. Neurochemistry International.2024.105861. Epub 2024 Sep 20.

3、Wenhao Shao#, Huaxing Ding#, Yan Wang, Zhiyong Shi, Hezhao Zhang, Fanxiu Meng, Qingyao Chang, Haojiang Duan, Kairui Lu,Li Zhang*,Jun Xu*.Key genes and immune pathways in T-cell mediated rejection postliver transplantation identified via integrated RNA-seq and machine learning.Scientific Reports 2024 Oct 16;14(1):24315.

4、Rui Cao, Yurong Liu, KaixinWei, Ning , Yuxiang , RuifangAo, Weiwei Pan, XiangWang, XiuweiWang*,Li Zhang*& Jun Xie*. Genes related to neural tube defects and glioblastoma.Scientific Reports 2025 Jan 30;15(1):3777.

5、Xiuwei Wang, Kaixin Wei, Min Wang**,Li Zhang*. Identification of potential key ferroptosis and autophagy-related genes in myelomeningocele through bioinformatics analysis. Heliyon 2024 Apr 30;10(8):e29654.

6、Haojiang Duan, Qingyao Chang, Huaxing Ding, Wenhao Shao, Yan Wang, Kairui Lu,Li Zhang*, Jun Xu*. GBP1 promotes acute rejection after liver transplantation by inducing Kupffer cells pyroptosis. Biochim Biophys Acta Mol Basis Dis. 2024 Dec 26:167644.

7、Yuxuan Zhang，Qingjuan Li, Yuhu Niu, Kaixin Wei, Xiuwei Wang, Bo Niu，Li Zhang*. Research progress on aging mechanism and drugs and the role of stem cells in anti-aging process. Experimental Gerontology. 2023 Aug;179.doi: 10.1016/j.exger.2023.112248.

8、Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu*, Jun Xu* and Jun Xie*. Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway. Epigenetics & Chromatin. 2021 Dec 4;14(1):52.doi: 10.1186/s13072-021-00426-3.

9、Zhang L, Dong Y, Wang W, Zhao T, Huang T, Khan A, Wang L, Liu Z, Xie J and Niu B. Ethionine Suppresses Mitochondria Autophagy and Induces Apoptosis via Activation of Reactive Oxygen Species in Neural Tube Defects. Front Neurol. 2020 Apr 7;11:242.

10、Li Zhang, Dandan Li, Juan Zhang, Ping Yan, Ajab Khan, Xueqin Liu, Lei Wang, Zhizhen Liu, Jianbing Mu, Jun Xu, Bo Niu*, Jun Xie*. Excessive apoptosis and ROS induced by ethionine affects neural cells viability and differentiation[J]. Acta Biochimica et Biophysica Sinica 2020 Oct 19;52(10).