姓名：王妍性别：女政治面貌：中共党员学历：研究生学位：博士职称：讲师

博、硕导师：硕导本岗位工作年数：4年

研究方向：移植免疫、肿瘤免疫、感染免疫

荣誉称号：山西医科大学2023-2024年度“青年五四奖章”

山西医科大学第一医院“优秀共产党员”（2023年）

学术任职：无

近五年承担科研课题情况：

1.国家自然科学基金委员会,青年科学基金项目,项目名称：PRAK通过NEDD4L-PAD4调控系统性红斑狼疮中中性粒细胞胞外诱捕网形成的机制研究,项目编号:32200717

2.山西省基础研究计划（自由探索类）青年项目，项目名称：PRAK介导的氧化应激反应对Th17细胞分化的调节在肝细胞癌中的作用，项目编号：2021002124092

代表性论著及近五年的代表性论文（限10项以内）：

1. Zhao Ziheng#,Wang Yan#, Gao Yuhan, Ju Yurong, Zhao Ye, Wu Zhaofei, Gao Shuaixin , Zhang Boyang, Pang Xuewen, Zhang Yu, and Wang Wei; The PRAK-NRF2 axis promotes the differentiation of Th17 cells by mediating the redox homeostasis and glycolysis, Proc Natl Acad Sci U S A. 2023, 120(19): e2212613120

2.Wang Yan, Wang Yuqing, Wu Jia, Liu Chen, Zhou Yu, Mi Ligu, Zhang Yu, Wang Wei; PRAK Is Required for the Formation of Neutrophil Extracellular Traps, Frontiers in Immunology, 2019, 10: 1252

3. Li Manyu#,Wang Yan#, Li Kejian, Lan Haiyun and Zhou Cheng；Characterization of highly expressed novel hub genes in hepatitis E virus chronicity in rabbits: abioinformatics and experimental analysis，BMC Veterinary Research，2022,18:239

4. Li Xinqiang#, Li Shipeng#,Wang Yan, Zhou Xin, Wang Feng, Muhammad Imran, Luo Yurong, Sun Yandong, Liu Dan, Wu Bin, Teng Dahong, Wang Jinshan, Zhao Kai, Ling Qi, Cai Jinzhen; Single cell RNA-sequencing delineates CD8+ tissue resident memory T cells maintaining rejection in liver transplantation, THERANOSTICS, 2024, 14(12): 4844-4860

5. Wang Yuqing#, Wang Wei#, Wu Haoming, Zhou Yu, Qin Xiaodan,Wang Yan, Wu Jia, Sun Xiuyuan, Yang Yan, Xu Hui, Qian Xiaoping, Pang Xuewen, Li Yan, Zhang Zhiqian, Han Hiahuai, Zhang, Yu; The essential role of PRAK in tumor metastasis and its therapeutic potential, Nature Communications, 2021, 12(1): 1736

6. Zhou Xiao Albert#, Zhou Jiadong#, Zhao Long, Yu Guihui, Zhan Jun, Shi Chanyi, Yuan Ruoshi,Wang Yan, Chen Changfeng, Zhang Wenjia, Xu Donghao, Ye Yingjiang, Wang Weibin, Shen Zhanlong*, Wang Wei*, Wang Jiadong* ; KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression, Proceedings of the National Academy of Sciences of the United States of America,2020, 117(45): 2839-2850

7. Mi Ligu,Wang Yan, Xu Hui, Wang Yu, Wu Jia, Dai Hui*, Zhang Yu*; PRAK Promotes the Pathogen Clearance by Macrophage Through Regulating Autophagy and Inflammasome Activation, Frontiers in Immunology, 2021, 12: 618561